Anti-Human TNF-Related Weak Inducer of Apoptosis (TWEAK)

Anti-Human TNF-Related Weak Inducer of Apoptosis (TWEAK)

Product No.: T309

[product_table name="All Top" skus="T309"]

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Target
TWEAK
Product Type
Polyclonal Antibody
Alternate Names
TNF-Related Weak Inducer of Apoptosis, TNFSF12, DR3LG, Apo3-Ligand
Applications
IHC FFPE
,
WB

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TWEAK recognizes Human, Mouse and Rat TWEAK. This polyclonal antibody was purified using affinity chromatography.
Background
TNF-related weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family1 that has pleiotropic biological functions including proapoptotic, proangiogenic and proinflammatory activities.2 TWEAK induces skeletal muscle atrophy.3 TWEAK functions both as a type II transmembrane protein and as a cleaved soluble protein. TWEAK transcripts are expressed in heart, brain, skeletal muscle, pancreas, immune system, ovary, and placenta.4

Antigen Details

PubMed

References & Citations

1. Burkly, LC. et al. (2005) Oncogene 24: 2613
2. Young, LS. et al. (2003) Biochem Biophys Res Commun. 305: 789
3. Kumar, A. et al. (2007) FASEB J. 21: 1857
4. Hsueh, A. et al. (2006) Molecular Endo. 20: 2528
IHC FFPE
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.