Recombinant Mouse EGF

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Pricing & Details

Product. No.E120
Alternate Names
Epidermal Growth Factor, Urogastrone, URG, C-erbB
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
Avail.
Qty
Add to cart
E120-200 µg
200 µg
$239.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Background

Epidermal growth factor (EGF), also known as Urogastrone, is a growth factor that plays an important role in the regulation of cell growth, proliferation and differentiation (1). It is produced by many cell types, in blood and various body fluids, including milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (2). EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface, activating an extensive network of signal transduction pathways that include PI3K/AKT, RAS/ERK and JAK/STAT. It is also a mitogen for fibroblasts, epithelial and endothelial cells, and promotes colony formation of epiderma. EGF has been shown to regulate tumor cell invasion through MMP-2 activation in various tumor cell types (3). Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing (4). Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development.

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
nsypgcpss ydgyclnggv cmhiesldsy tcncvigysg drcqtrdlrw welr
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse EGF is Mr 6.2 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Carpenter, G. et al. (1986) J. Biol. Chem. 265:770
2. Cosen-Binker, LI. et al. (2009) Biochem. Biophys. Res. Commun. 379:445
3. Machowska, A. et al. (2008) Inflammopharmacol. 16:40
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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