Recombinant Mouse FGF R3 (IIIc)

Fibroblast growth factor receptor 3 is receptor tyrosine kinases expressed on most types of cells.¹ FGFR3 protein plays a role in the development and maintenance of bone and brain tissue and has several important cellular functions such as regulation of cell growth and division, determination of cell type, formation of blood vessels, wound healing, and embryo development.² FGFR3 result in autosomal dominant human skeletal dysplasias and is a major cause of benign epidermal tumors in humans.³

Fc Fusion Protein

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Ala33

Lyophilized

The predicted molecular weight of Recombinant Mouse FGF R3 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100-110 kDa.

63

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Hicks, D. et al. (1999) J Mol Neurosci. 13: 187
2. Hartmann, A. et al. (2006) J Clin Invest. 116(8):2201-2207.
3. Radvanyi, F. et al. (2005) Human Molecular Genetics 14: 1153