Recombinant Mouse IL-2

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Pricing & Details

Product. No.I-218
Alternate Names
Interleukin-2, TCGF, Lymphokine, T-Cell Growth Factor
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-218-20 µg
20 µg
$239.00
In stock
Max:
Min: 1
Step: 1
I-218-100 µg
100 µg
$739.00
In stock
Max:
Min: 1
Step: 1
I-218-500 µg
500 µg
$1,771.00
In stock
Max:
Min: 1
Step: 1

Background

IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
maptssstss staeaqqqqq qqqqqqqhle qllmdlqell srmenyrnlk lprmltfkfy lpkqatelkd lqcledelgp lrhvldltqs ksfqledaen fisnirvtvv klkgsdntfe cqfddesatv vdflrrwiaf cqsiistspq
N-terminal Sequence Analysis
Ala21 & Met
State of Matter
Solution
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-2 is Mr 17.2 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is 19 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and is supplied in a sterile solution in Ammonium Acetate and DTT.
Storage and Stability
This recombinant protein can be stored at 2° to 8°C as supplied for six months. Do not freeze.
Country of Origin
USA
Shipping
Polar Packs
PubMed
NCBI Gene Bank

References & Citations

1. Schachter, J. et al. (2009) Cytotherapy 11: 206
2. Sodora, DL. et al. (2009) Curr HIV Res. 7: 83
3. Alcocer-Varela, J. et al. (2009) Autoimmun Rev. 9(1):34-9.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.