BackgroundIL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease. Protein DetailsPurity >97% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Expression Host E. coli Protein Accession No. Amino Acid Sequence maptssstss staeaqqqqq qqqqqqqhle qllmdlqell srmenyrnlk lprmltfkfy lpkqatelkd lqcledelgp lrhvldltqs ksfqledaen fisnirvtvv klkgsdntfe cqfddesatv vdflrrwiaf cqsiistspq
N-terminal Sequence Analysis Ala21 & Met State of Matter Solution Predicted Molecular Mass The predicted molecular weight of Recombinant Mouse IL-2 is Mr 17.2 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is 19 kDa. Formulation This recombinant protein was 0.2 µm filtered and is supplied in a sterile solution in Ammonium Acetate and DTT. Storage and Stability This recombinant protein can be stored at 2° to 8°C as supplied for six months. Do not freeze. Country of Origin USA Shipping Polar Packs PubMed NCBI Gene Bank References & Citations1. Schachter, J. et al. (2009) Cytotherapy 11: 206 2. Sodora, DL. et al. (2009) Curr HIV Res. 7: 83 3. Alcocer-Varela, J. et al. (2009) Autoimmun Rev. 9(1):34-9. IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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