Interleukin 7 (IL-7) is a glycoprotein cytokine initially referred to as pre-B cell growth factor because of its growth-promoting activity for cells early in the B lymphocyte lineage. Subsequent to IL-7 gene cloning and expression, IL-7 was also found to influence the activity of cells in the T lineage.1 IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. It also stimulates proliferation of all cells in the lymphoid lineage (B and T lymphocytes and NK cells). IL-7 is not only a potent grown stimulus for pre-B cells, but also plays a role in T cell activation.2 IL-7 has significant clinical and biomedical potential, such as cancer therapy and HIV infections.3
>97% by SDS-PAGE and analyzed by silver stain.
<0.01EU/µg as determined by the LAL method
The biological activity of Mouse IL-7 was determined in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (Yokota, T. et al., 1986, Proc. Natl. Acad. Sci. USA 83:5894). The expected ED50 for this effect is typically 0.15 - 0.3 ng/ml.
Protein Accession No.
Amino Acid Sequence
mechikdkeg kayesvlmis ideldkmtgt dsncpnnepn ffrkhvcddt keaaflnraa rklkqflkmn iseefnvhll tvsqgtqtlv nctskeeknv keqkkndacf lkrllreikt cwnkilkgsi
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-7 is Mr 15 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Namen, AE. et al. (1990) Int J Cell Cloning 1: 168
2. Reed, SG. et al. (1989) J Exp Med. 169: 707
3. Prakash, S. et al. (2008) Appl. of Biochem Biotechnol. 151: 93
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.