Recombinant Mouse Resistin

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Pricing & Details

Product. No.R1135
Alternate Names
Adipocyte-Specific Secretory Factor (ADSF), Inflammatory Zone 3 (FIZZ3), MGC126603, MGC126609, RETN1, RSTN, CEBPE Regulated Myeloid-Specific Secreted Cysteine-Rich Protein Precursor 1 (XCP1)
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
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Qty
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R1135-50 µg
50 µg
$249.00
In stock
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Min: 1
Step: 1

Background

Resistin, also known as ADSF, RETN, CEBPE, is a cysteine-rich protein that belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. Resistin is secreted by adipocytes, pituitary and hypothalamus with potential roles in insulin resistance and adipocyte differentiation (1-2). In addition, Resistin functions as a regulator of glucose homeostasis and a physiologic antagonist to hepatic insulin action (3). Resistin may be an important mediator of obesity-induced insulin resistance and may represent a novel link between metabolic signals, inflammation, and atherosclerosis (4-5).

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse Resistin was determined by its ability to inhibit mouse 3T3-L1 cell adipocyte differentiation. The expected ED50 for this effect is typically 5-25 µg/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
ssmplcpide aidkkikqdf nslfpnaikn iglncwtvss rgklascpeg tavlscscgs acgswdiree kvchcqcari dwtaarcckl qvas
N-terminal Sequence Analysis
Ser21
State of Matter
Lyophilized
Predicted Molecular Mass
Recombinant mouse Resistin contains a mixture of monomeric and disulfide-linked homodimeric proteins. The predicted molecular weight of Recombinant Mouse Resistin monomer is Mr 10 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable ≥ twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution and addition of a carrier protein, this protein may be stored under sterile conditions at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Lazar, MA. et al. (2001) J. Biol. Chem. 276:25970
2. Lazar, MA. et al. (2002) J. Biol. Chem. 277:19754
3. Wolf, G. et al. (2004) Nutr. Rev. 62:389
4. Chen, R. et al. (2004) Eur. J. Endocrinol. 150:885
5. Rader, DJ. et al. (2005) Circulation 111:9
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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