Antibody DetailsProduct DetailsReactivity Species Human Host Species Mouse Product Concentration 0.1 mg/ml Formulation This DyLight® 800 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 800 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2828941 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this UCHM-1 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone UCHM-1 recognizes an epitope on human CD14. Antigen Distribution CD14 is expressed on monocytes, macrophages, dendritic cells, and granulocytes. Background CD14 is a 53-55 kD GPI-anchored single chain glycoprotein that plays a role in the clearance of gram-negative pathogens by interacting with other proteins, including TLR-4 and MD-2, to mediate the innate immune response to bacterial lipopolysaccharide (LPS). As a high-affinity receptor for LPS, it is involved in the upregulation of adhesion molecules and cytokine expression in monocytes and neutrophils. Antigen DetailsProtein Ligand/Receptor LPS. PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Biology . Immunology . Neuroinflammation . Neuroscience References & Citations1. Ulrich Costabel et al. (1995) CHEST 108: 1614
2. Ulevitch RJ et al. (1993) Immunobiology 187: 227
3. Schumann RR et al. (1994) Medical Microbiol Immunol. 183: 279
4. Verhasselt V et al. (1997) J Immunol. 158: 2919
5. Kirkland TN et al. (2000) J Biol Chem. 275: 3144 Technical Protocols |
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