Anti-Human CD8 [Clone UCHT-4] — CF® 700
Anti-Human CD8 [Clone UCHT-4] — CF® 700
Product No.: C2065
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Clone UCHT-4 Target CD8 Formats AvailableView All Product Type Monoclonal Antibody Isotype Mouse IgG2a Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified Recombinant Human CD8 (>98%) Product Concentration 0.2 mg/ml Formulation This CF® 700 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, with 0.09% sodium azide as a preservative. and BSA (USA Origin) Storage and Handling This CF® 700 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Optimized for 633 nm, 635 nm, 680 nm, or 685 nm red/near-infrared (NIR) laser lines Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this UCHT-4 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Emission Max 721 nm DescriptionDescriptionSpecificity Clone UCHT-8 recognizes human CD8. Background CD8 is a cell-surface glycoprotein that serves as a critical co-receptor for the T-cell receptor (TCR). It is predominantly used as a phenotypic marker for cytotoxic T cells, NK cells, and thymocytes. - Immune Function: Binds to MHC Class I molecules to facilitate antigen recognition and cell-to-cell interaction. - T-Cell Signaling: Interacts with Lck kinase to activate transcription factors essential for the adaptive immune response. 1 Research Utility: Clone UCHT-4 reliably targets the human CD8 antigen, optimized for precise detection in flow cytometry and immunological assays. Antigen Distribution CD8 is expressed on blood lymphocytes, a subset of NK cells, and thymocytes. Persons with HIV exhibit increased levels of CD8+ lymphocytes. Ligand/Receptor MHC Class I molecules PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology References & Citations1. Parnes, J. R. et al. (1989) Adv. Immunol. 44:265
2. Reinherz, E. L. et al. (1980) J. Immunol. 124:1301
3. Fischer, A. et al. (1983) Immunology 48:177
4. Merkenschlanger, M. et al. (1988) Eur. J. Immunol. 18:1653
5. Leukocyte Typing: 3rd Workshop: Code No. 567; 4th Workshop: Code No. N31 Technical Protocols Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
