Anti-Human CIDE-A (CT)

Pricing & Details

Product No.C1292
Protein
CIDE-A
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Cell death-Inducing DFF-like Effector
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1292-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1292-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1136
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human CIDE-A recognizes an epitope near the C-terminus of Human CIDE-A. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified.1 CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD.1,2 Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-A is expressed in many tissues.

Antigen Details

Protein
PubMed

References & Citations

1. Liu, X. et al. (1997) Cell. 89(2):175-84.
2. Enari, M. et al. (1998) Nature. 391(6662):43-50.
3. Sakahira, H. et al. (2015) Nature. 526(7575):728.
4. Liu, X. et al. (1998) Proc Natl Acad Sci U S A. 95(15):8461-6.
5. Inohara, N. et al. (1998) EMBO J. 17(9):2526-33.
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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