Anti-Human TRIM5α (Intermediate Domain 2)

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Pricing & Details

Product No.T333
Protein
TRIM5α
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T333-20 µg
20 µg
$115.00
In stock
Max:
Min: 1
Step: 1
T333-0.1 mg
0.1 mg
$425.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TRIM5α recognizes an epitope in the intermediate domain of Human TRIM5α. This polyclonal antibody was purified using affinity chromatography.
Background
TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region.1 TRIM5 has six alternately spliced isoforms, the longest of which is the variant which also contains a carboxy-terminal B30.2 (SPRY) domain.1 Expression of TRIM5α variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1,2,3 albeit at differing efficiencies. All TRIM5α variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5α acts as a natural barrier to cross-species retrovirus transmission.3

Antigen Details

Protein
PubMed

References & Citations

1. Reymond, A. et al. (2001) EMBO J. 20:2140 2. Stremlau, M. et al. (2004) Nature 427:848 3. Hatziioannou, T. et al. (2004) Proc. Nat’l. Acad. Sci. USA 101:10774
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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