Anti-Mouse CD80 (Clone 111114)

Pricing & Details

Product No.B584
Clone
111114
Protein
CD80
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
B71, Ly53, TSA1, Cd28l, Ly-53, MIC17
Isotype
Rat
IgG2a
Applications
IHC
Prod No.
Size
Price
Avail.
Qty
Add to cart
B584-25 µg
25 µg
$225.00
In stock
Max:
Min: 1
Step: 1
B584-500 µg
500 µg
$525.00
In stock
Max:
Min: 1
Step: 1
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Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Rat
Immunogen
NS0-Derived Recombinant Mouse B7-1 (Accession # Q00609)
Formulation
This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Storage and Handling
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Other Applications Reported In Literature ?
Immunohistochemistry: Suitable for use at concentration of 5-25 µg/mL.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 111114 recognizes an epitope on mouse B7-1.
Antigen Distribution
CD80 is expressed on activated B cells, monocytes/macrophages, and dendritic cells.
Background
CD80 is a highly glycosylated 60 kD protein that is part of the Ig superfamily and is significantly involved in immune cell activation in response to pathogens. CD80 is closely related to, and works in tandem with CD86 (B7-2) to prime T- cells. CD80 binds to CTLA-4 to deliver an inhibitory signal to T cells. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. It is thought that CD80 interacts with a ligand on Natural Killer cells, activating the Natural Killer cell-mediated cell death of the CD80 carrier. The activation of Natural Killer cell-mediated death via CD80 interactions has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells.

Antigen Details

Protein
PubMed
NCBI Gene Bank ID
IHC

Formats Available

Prod No.
Description
B584
Products are for research use only. Not for use in diagnostic or therapeutic procedures.