Anti-Mouse Gas6 (Clone 126618)

Product No.: G680


Clone 126618 Target Gas6 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names AXLLG, AXSF, DKFZp666G247, FLJ34709, Growth Arrest Specific 6 Isotype IgG2a Applications ELISA Indirect , WB


Select Product Size 25 µg — $274.00 500 µg — $620.00	Qty Max: Min: 1 Step: 1 Select A Size ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities


Antibody Details Product Details Reactive Species Mouse Host Species Rat Immunogen NS0-Derived Recombinant Mouse Gas6 Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. Storage and Handling The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830269 Applications and Recommended Usage? Quality Tested by Leinco Indirect ELISA: This antibody can be used in an indirect detection ELISA at 0.5 - 1.0 µg/ml with a suitable second step reagent such as PN:R380. The detection sensitivity of this indirect ELISA for Mouse Gas6 is approximately 1 ng/well. Western Blotting: To detect Mouse Gas6 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:R377 and a chromogenic substrate such as PN:T343. The detection limit for Mouse Gas6 is 5 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Rat Anti-Mouse Growth Arrest Specific Protein 6 (Gas6) (Clone 126618) recognizes an epitope on Mouse Gas6. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Growth arrest-specific 6, also known as GAS6 is a growth factor¹ that serves as a ligand for members of the Axl subfamily of receptor protein-tyrosine kinases.² GAS6 is expressed in hematopoietic tissue.³ GAS6 function as a direct regulator of osteoclastic function; they give an insight into the role of these vitamin K-dependent ligands in bone resorption in vivo.² GAS6 has a potential therapeutic target to minimize graft-versus-host disease (GVHD).⁴ PubMed Gas6 NCBI Gene Bank ID 14456 UniProt.org More Information on Uniprot.org References & Citations 1. Suda, T. et al. (1998) Stem Cells 16: 229 2. Schneider, C. et al. (2001) Mol Cell Biol. 21: 902 3. Aglietta, M. et al. (1997) Exp Hematol. 25: 1219 4. Angelillo-Scherrer, A. et al. (2005) J Clin Invest. 115(2):237-46. View product citations for antibody G680 on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Mouse

Host Species

Rat

Immunogen

NS0-Derived Recombinant Mouse Gas6

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Formulation

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Storage and Handling

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Country of Origin

USA

Shipping

Next Day Ambient

RRIDAB_2830269

Applications and Recommended Usage?
Quality Tested by Leinco

Indirect ELISA: This antibody can be used in an indirect detection ELISA at 0.5 - 1.0 µg/ml with a suitable second step reagent such as PN:R380. The detection sensitivity of this indirect ELISA for Mouse Gas6 is approximately 1 ng/well.
Western Blotting: To detect Mouse Gas6 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:R377 and a chromogenic substrate such as PN:T343. The detection limit for Mouse Gas6 is 5 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rat Anti-Mouse Growth Arrest Specific Protein 6 (Gas6) (Clone 126618) recognizes an epitope on Mouse Gas6. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background

Growth arrest-specific 6, also known as GAS6 is a growth factor¹ that serves as a ligand for members of the Axl subfamily of receptor protein-tyrosine kinases.² GAS6 is expressed in hematopoietic tissue.³ GAS6 function as a direct regulator of osteoclastic function; they give an insight into the role of these vitamin K-dependent ligands in bone resorption in vivo.² GAS6 has a potential therapeutic target to minimize graft-versus-host disease (GVHD).⁴

PubMed

Gas6

NCBI Gene Bank ID

14456

UniProt.org

More Information on Uniprot.org

References & Citations

1. Suda, T. et al. (1998) Stem Cells 16: 229
2. Schneider, C. et al. (2001) Mol Cell Biol. 21: 902
3. Aglietta, M. et al. (1997) Exp Hematol. 25: 1219
4. Angelillo-Scherrer, A. et al. (2005) J Clin Invest. 115(2):237-46.

View product citations for antibody G680 on CiteAb

Certificate of Analysis

Request COA

Prod No.	Description
G680	Anti-Mouse Gas6 (Clone 126618)
G659	Anti-Mouse Gas6
G656	Anti-Mouse Gas6 – Biotin

Formats Available

Prod No.	Description
G680	Anti-Mouse Gas6 (Clone 126618)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

NEW Products!

Anti-Mouse Gas6 (Clone 126618)