Recombinant Mouse MIP-3α

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Pricing & Details

Product. No.M201
Alternate Names
CCL20, CKb4, Liver Activation Regulated Chemokine (LARC), MIP3A, SCYA20, ST38, Exodus-1
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
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Qty
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M201-25 µg
25 µg
$359.00
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Min: 1
Step: 1

Background

Macrophage Inflammatory Protein-3 Alpha (MIP3A) also known as CCL20 or liver activation regulated chemokine (LARC) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.1 MIP3A is specifically expressed by the follicle-associated epithelia (FAE) covering intestinal Peyer's patches (PPs) and is the only known chemokine ligand for the chemokine receptor CCR6.2 MIP3-alpha is produced by intestinal epithelial cells (including cells associated with mucosal lymphoid tissues), by keratinocytes in inflamed skin, and by cells in liver and lung.3,4 It plays an important role in the inflammatory response of blood monocytes and tissue macrophages.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse MIP-3α was determined by its ability to chemoattract mouse BaF/3 cells transfected with hCCR6. The expected ED50</sub for the chemotactic effect is typically 2 - 6 ng/ml.
Expression Host
E. coli
Protein Accession No.
Q642U4
Amino Acid Sequence
asny dcclsyiqtp lpsraivgft rqmadeacdi naiifhtkkr ksvcadpkqn wvkravnlls lrvkkm
N-terminal Sequence Analysis
Ala27
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse MIP-3α is Mr 7.9 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Nomiyama, H. et al. (1997) J. Biol. Chem. 272: 5846
2. Kucharzik, T. et al. (2005) J. Pathol. 166: 1647
3. Cook, DN. et al. (2000) Immunity 12: 495
4. Farber, JM. et al. (2002) J. Immunol. 168: 4871
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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