Recombinant Rat IL-4

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Pricing & Details

Product. No.I-221
Alternate Names
Interleukin-4, BCGF, BCDF, B Cell Stimulating Factor, BSF-1
Expression Host
E. coli
Species
Rat
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-221-5 µg
5 µg
$219.00
In stock
Max:
Min: 1
Step: 1
I-221-25 µg
25 µg
$639.00
In stock
Max:
Min: 1
Step: 1

Background

IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
cndsplreii ntlnqvtekg tpctemfvpd vltatrntte nelicrasrv lrkfyfprdv ppclknksgv lgelrklcrg vsglnslrsc tvnestlttl kdfleslksi lrgkylqsct sms
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Rat IL-4 is Mr 13.5 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed

References & Citations

1. Pike, JW. et al. (2001) PNAS 98: 2443
2. Finkelman, FD. et al. (2003) J Immunol. 170: 3835
3. Kaplan, MH. et al. (2008) J Immunol. 180: 3551
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.