Enabling Faster Time to Results with in vivo Functional Grade Antibodies

In vivo functional grade antibodies can take your research from initial hypothesis to in vivo animal studies

With their ability to activate, neutralize or block the activity of their antigen, these antibodies are powerful tools for elucidating the function of a specific protein as well as interrogating the physiological impact of disrupting the protein’s normal function. In vivo functional grade antibodies are suitable for numerous areas of research, including:

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Generate superior and trusted data with in vivo grade functional antibodies from Leinco Technologies

Leinco Technologies has developed an extensive technology tool box for the manufacturing of monoclonal antibodies for in vitro cellular based experiments or in vivo functional studies in animal models. Reproducibility of pre-clinical studies is paramount in driving research forward towards life-saving therapies and diagnostics. However, the scientific community is facing a “reproducibility crisis,” with 70% of respondents to a recent Nature survey* stating that they have been unable to repeat published results. A significant portion of the reproducibility problem is due to impurities and other variables between similar biological reagents and reference materials. Leinco Technologies aims to solve this problem by offering antibodies that meet the highest purity standards in the industry, with low endotoxin levels (<0.5EU/mg) and minimal aggregates (≥98% monomers as measured by SEC) enabling reproducible science and reliable data. Produced in our cGMP and ISO-certified facility, these in vivo functional antibodies are amenable to a variety of research projects, from in vitro cellular studies to long-term in vivo animal studies. Each antibody is available in custom concentrations and package sizes. In vivo PLATINUMTM antibodies are also pathogen-free and tested by the IDEXX Impact I PCR mouse pathogen profile.

IDEXX IMPACT I (PCR-based) Mouse Pathogen Profile for Purified In vivo PLATINUM™ Grade Antibodies

Lot-to-lot reproducibility enables reproducible science

Antibody consistency is fundamental to reproducible science. Our lot-to-lot quality control (below) demonstrates the superior purity and reproducibility of our antibodies.

Figure 1. Quality control of 9 in vivo antibodies: RMP1-14

In vivo antibodies from Leinco Technologies are subjected to extensive QC to ensure high reproducibility between lots. The example in Figure 1 shows the results for nine lots of RMP1-14 antibody, directed against PD-1. The lots have consistently high purity as indicated by non-reducing and reducing SDS-PAGE (Fig. 1A and 1B). Analysis by size exclusion chromatography gave superimposing chromatograms for all nine lots, with overlapping retention times and minimal baseline noise (Fig. 1C). Endotoxin data for eight lots indicated that all lots were below the specification of ≤ 0.5 EU/mg as determined by the limulus amebocyte lysate (LAL) method (Fig. 1D).

Pure and consistent antibodies avoid potential experimental pitfalls