Purified Recombinant Human CD57 (>98%)
This PerCP conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This PerCP conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Mouse Anti-Human CD57 (Clone VC1.1) recognizes an epitope on Human CD57. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system.
Anti-CD57 may be used in flow cytometry, Western blotting and immunohistology on formalin fixed paraffin embedded tissue sections. The antibody is useful for enumeration of NK subsets and T-lymphocyte subsets, studies of neural tissue, malignant tissues and AIDS-related complex.
Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
NCBI Gene Bank ID
References & Citations
1. Barnstable, C. et al. (1995) Brain Research 559:118 2. Leukocyte Typing V (1995) Oxford University Press: Code No. NK67 3. Arimatsu, Y. et al. (1987) J. Neuroscience 7:1250 4. Abo, T., and Balch, C.M. et al. (1981) J. Immunol. 127:1024
Products are for research use only. Not for use in diagnostic or therapeutic procedures.