Anti-Human CD57 (Clone VC1.1) – Purified

Home/Primary Monoclonal Antibodies/SurfaceTag Human CD Markers/Anti-Human CD57 (Clone VC1.1) – Purified

Pricing & Details

Product No.C287
Clone
VC1.1
Protein
CD57
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
HNK-1, Natural Killer Cells
Isotype
Mouse
IgM
Applications
FC
,
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C287-50 µg
50 µg
$71.00
In stock
Max:
Min: 1
Step: 1
C287-100 µg
100 µg
$118.00
In stock
Max:
Min: 1
Step: 1
C287-200 µg
200 µg
$207.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human CD57 (Clone VC1.1) recognizes Human CD57. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Anti-CD57 recognizes a (Mr 110 kD) carbohydrate molecule on myeloid cells. This surface antigen is associated with myelin-associated glycoprotein (MAG).1 This antibody blocks binding of HNK-1 (Leu. 7) antibody.3
Antigen Distribution
The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system.
Background
Anti-CD57 may be used in flow cytometry, Western blotting and immunohistology on formalin fixed paraffin embedded tissue sections. The antibody is useful for enumeration of NK subsets and T-lymphocyte subsets, studies of neural tissue, malignant tissues and AIDS-related complex.

Antigen Details

Protein
Ligand/Receptor
Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
PubMed
NCBI Gene Bank ID
Research Area
Costimulatory Molecules
.
Immunology

References & Citations

1. Barnstable, C. et al. (1995) Brain Research 559:118
2. Leukocyte Typing V (1995) Oxford University Press: Code No. NK67
3. Arimatsu, Y. et al. (1987) J. Neuroscience 7:1250
4. Abo, T., and Balch, C.M. et al. (1981) J. Immunol. 127:1024
Flow Cytometry
IHC
General Western Blot Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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