Anti-Human CD62L [Clone DREG-56] — Alexa Fluor® 647
Anti-Human CD62L [Clone DREG-56] — Alexa Fluor® 647
Product No.: C2279
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Clone DREG-56 Target CD62L Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names L-selectin, LECAM-1, LAM-1, Leu-8, TQ-1 Isotype Mouse IgG1 κ Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Product Concentration 0.2 mg/ml Formulation This Alexa Fluor® 647 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Alexa Fluor® is a trademark of Life Technologies Corporation. State of Matter Liquid Storage and Handling This Alexa Fluor® 647 conjugate is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2-8°C Wet Ice Excitation Laser Red Laser (633 nm) Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm. RRIDAB_2829367 Applications and Recommended Usage? Quality Tested by Leinco FC Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone DREG-56 recognizes an epitope on human CD62L. Background CD62L antibody, clone DREG-56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes1. Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition2,3. Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer’s patches, via high endothelial venules (HEVs)1. CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation4.
Antigen Distribution CD62L is expressed on most circulating leukocytes, including neutrophils, monocytes, T, B and NK cells, and human embryo trophoblasts. Ligand/Receptor CD34, GlyCAM, MAdCAM-1 Function Leukocyte homing, leukocyte tethering, rolling PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Adhesion . Cell Biology . Costimulatory Molecules . Immunology . Innate Immunity References & Citations1. Ivetic A, et al. (2019) Front Immunol. 10:1068 2. Varki A (1994) Proc Natl Acad Sci USA. 91(16):7390-7397 3. Rosen SD. (1999) Am J Pathol. 155(4):1013-1020 4. Genbacev OD, et al. (1003) Science. 299(5605):405-8 Technical Protocols Certificate of Analysis |
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Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
