Anti-Human CD62L - Biotin - Leinco Technologies

Anti-Human CD62L – Biotin

Product No.: C2272


Clone DREG56 Target CD62L Formats AvailableView All Product Type Monoclonal Antibody Alternate Names TQ1, LAM1, LEU8, LNHR, LSEL, CD62L, LYAM1, PLNHR, LECAM1 Isotype IgG1 Applications FC


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Antibody Details Product Details Reactive Species Human Host Species Mouse Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829360 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this DREG56 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 10⁶ cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Clone DREG56 recognizes an epitope on human CD62L. Background CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes¹. Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition^2,3. Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer’s patches, via high endothelial venules (HEVs)¹. CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation^{4^.} Antigen Distribution CD62L is expressed on most circulating leukocytes, including neutrophils, monocytes, T, B and NK cells, and human embryo trophoblasts. Ligand/Receptor CD34, GlyCAM, MAdCAM-1 Function Leukocyte homing, leukocyte tethering, rolling PubMed CD62L NCBI Gene Bank ID 6402 UniProt.org Information on Uniprot.org Research Area Cell Adhesion . Cell Biology . Costimulatory Molecules . Immunology . Innate Immunity References & Citations 1. Ivetic A, et al. (2019) Front Immunol. 10:1068 2. Varki A (1994) Proc Natl Acad Sci USA. 91(16):7390-7397 3. Rosen SD. (1999) Am J Pathol. 155(4):1013-1020 4. Genbacev OD, et al. (1003) Science. 299(5605):405-8 View product citations for antibody C2272 on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Product Concentration

0.5 mg/ml

Formulation

This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Storage and Handling

This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

RRIDAB_2829360

Applications and Recommended Usage?
Quality Tested by Leinco

FC The suggested concentration for this DREG56 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 10⁶ cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Clone DREG56 recognizes an epitope on human CD62L.

Background

CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes¹. Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition^2,3. Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer’s patches, via high endothelial venules (HEVs)¹. CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation^{4^.}

Antigen Distribution

CD62L is expressed on most circulating leukocytes, including neutrophils, monocytes, T, B and NK cells, and human embryo trophoblasts.

Ligand/Receptor

CD34, GlyCAM, MAdCAM-1

Function

Leukocyte homing, leukocyte tethering, rolling

PubMed

CD62L

NCBI Gene Bank ID

6402

UniProt.org

Information on Uniprot.org

Research Area

Cell Adhesion

Cell Biology

Costimulatory Molecules

Immunology

Innate Immunity

References & Citations

1. Ivetic A, et al. (2019) Front Immunol. 10:1068
2. Varki A (1994) Proc Natl Acad Sci USA. 91(16):7390-7397
3. Rosen SD. (1999) Am J Pathol. 155(4):1013-1020
4. Genbacev OD, et al. (1003) Science. 299(5605):405-8

View product citations for antibody C2272 on CiteAb

Certificate of Analysis

Request COA

Prod No.	Description
C2275	Anti-Human CD62L – PerCP
C2276	Anti-Human CD62L – DyLight® 488
C2277	Anti-Human CD62L – DyLight® 550
C2278	Anti-Human CD62L – DyLight® 594
C2279	Anti-Human CD62L – DyLight® 650
C2274	Anti-Human CD62L – PE
C2273	Anti-Human CD62L – APC

Formats Available

Prod No.	Description
C2275	Anti-Human CD62L – PerCP
C2271	Anti-Human CD62L – FITC
C2140	Anti-Human CD62L – Purified
C2276	Anti-Human CD62L – DyLight® 488
C2277	Anti-Human CD62L – DyLight® 550
C2278	Anti-Human CD62L – DyLight® 594
C2279	Anti-Human CD62L – DyLight® 650
C512	Anti-Human CD62L – Purified (PhenoCyler-Fusion (CODEX)® Ready)
C2274	Anti-Human CD62L – PE
C2270	Anti-Human CD62L – Purified in vivo GOLD™ Functional Grade
C2273	Anti-Human CD62L – APC
C2272	Anti-Human CD62L – Biotin
C6270	Anti-Human CD62L – Purified in vivo PLATINUM™ Functional Grade

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Anti-Human CD62L – Biotin