Anti-Human CLC

E. coli-Derived Recombinant Human CLC

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

Lyophilized

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Next Day Ambient

Goat Anti-Human Novel Neurotrophin-1 (NNT-1) recognizes Human NNT-1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Cardiotrophin-like cytokine (CLC) also known as novel neurotrophin-1/B cell stimulating factor-3 (NNT-1/BSF-3) is a member of the interleukin (IL)-6 family of cytokines.¹ CLC is expressed highly in spleen and peripheral leukocytes² and is a target-derived factor required for the survival of specific pools of motoneurons.³ CLC shows neuroprotective effects on retinal ganglion cells (RGCs) in vivo and might be a treatment option for chronic neurodegenerative eye diseases such as glaucoma.⁴

1. Taga, T. et al. (2002) Cytokine 18(1):1-7.
2. Shi, Y. et al. (1999) Biochemical Biophysical Res Communications 262:132.
3. Oppenheim, RW. et al. (2003) J Neurosci. 23:8854.
4. Wen, R. et al. (2005) Graefes Arch Clin Exp Ophthalmol. 243(10):1036-42.