Anti-Mouse CCL1

Sf 21-Derived Recombinant Mouse CCL1

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

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Neutralization: This antibody is useful for neutralization of Mouse CCL1 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse CCL1 (at 0.01 ng/ml) is 0.3 - 1.5 µg/ml.

Goat Anti-Mouse CCL1 recognizes Mouse CCL1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines.¹ CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.² CCL1 may play a role in lymphocyte recruitment in bronchial asthma.³

1. Krangel, MS. et al. (1992) Proceedings of the National Acad of Sci. 89: 2950
2. Roos, RS. et al. (1997) J Biol Chem. 272: 17251
3. Teran, LM et al. (2006) Eur Respir J. 28: 59