Anti-Mouse CD28 [Clone 37.51] — Alexa Fluor® 647

Purified Recombinant Mouse CD28 (>98%)

This Alexa Fluor® 647 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Alexa Fluor® is a trademark of Life Technologies Corporation.

Liquid

This Alexa Fluor® 647; 650 conjugate is stable when stored at 2-8°C. Do not freeze.

Research Use Only

2-8°C Wet Ice

Red Laser (633 nm) Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

Clone 37.51 recognizes an epitope on mouse CD28.

CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.

CD28 is expressed on thymocytes, CD4+, CD8+ peripheral T cells, NK cells.

CD80 (B7-1), CD86 (B7-2)

1. Gross, J. A. et al. (1992) J. Immunol. 149:380