Anti-Mouse/Human IL-5 – APC

Anti-Mouse/Human IL-5 – APC

Product No.: I-1063

[product_table name="All Top" skus="I-1063"]

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Clone
TRFK5
Target
IL-5
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
BCDFII,Interleukin-5, IL5, B cell differentiation factor 1, TRF, EDF
Isotype
IgG1 κ
Applications
FC
,
ICC

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Product Concentration
0.2 mg/ml
Formulation
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Storage and Handling
This APC conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Red Laser (633 nm)
Applications and Recommended Usage?
Quality Tested by Leinco
Flow Cytometry:This antibody can be used at a concentration of ≤ 0.5 µg per 100 µl of whole blood (or per 1.0 x 106 cells in a 100 µl total staining volume). Each lot of this antibody is quality control tested.
Additional Applications Reported In Literature ?
Additional reported applications (for the relevant formats) include:
ELISA
Neutralization
Western Blotting
IHC-FFPE
IHC-FF
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone TRFK5 recognizes mouse/human IL-5.
Background
IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.

Antigen Details

Function
Growth/differentiation of B cells, eosinophils; proliferation/cell activation/differentiation of eosinophilic granulocytes
PubMed
NCBI Gene Bank ID
Flow Cytometry
ICC

Certificate of Analysis

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Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.