Anti-Mouse/Human IL-5 [Clone TRFK5] — Purified
Anti-Mouse/Human IL-5 [Clone TRFK5] — Purified
Product No.: I-1038
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Partially-purified T cell clone supernatant Product Concentration 0.5 mg/ml Formulation This Purified conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Product Preparation This monoclonal antibody was purified by affinity chromatography. Storage and Handling This Purified conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2830369 Applications and Recommended Usage? Quality Tested by Leinco ELISA:The purified monoclonal antibody clone TRFK5 is useful as a capture antibody for a sandwich ELISA, when used in conjunction with biotinylated TRFK4 antibody or JES1-5A10 as the detection antibody for mouse IL-5, Additional Applications Reported In Literature ? Additional reported applications (for the relevant formats) include: Neutralization Flow Cytometry Western Blotting IHC-FFPE IHC-FF Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone TRFK5 recognizes mouse/human IL-5. Background IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma. PubMed UniProt.org References & CitationsTechnical Protocols IHC FF IHC FFPE  Certificate of Analysis |
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