Anti-Mouse/Human IL-5 – Purified

Anti-Mouse/Human IL-5 – Purified

Product No.: I-1038

[product_table name="All Top" skus="I-1038"]

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Clone
TRFK5
Target
IL-5
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
BCDFII,Interleukin-5, IL5, B cell differentiation factor 1, TRF, EDF
Isotype
IgG1
Applications
ELISA Cap
,
IHC FF
,
IHC FFPE
,
WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Immunogen
Partially-purified T cell clone supernatant
Product Concentration
0.5 mg/ml
Formulation
This Purified conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation
This monoclonal antibody was purified by affinity chromatography.
Storage and Handling
This Purified conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA:The purified monoclonal antibody clone TRFK5 is useful as a capture antibody for a sandwich ELISA, when used in conjunction with biotinylated TRFK4 antibody or JES1-5A10 as the detection antibody for mouse IL-5,
Additional Applications Reported In Literature ?
Additional reported applications (for the relevant formats) include:
Neutralization
Flow Cytometry
Western Blotting
IHC-FFPE
IHC-FF
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone TRFK5 recognizes mouse/human IL-5.
Background
IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.

Antigen Details

PubMed
NCBI Gene Bank ID
Elisa Sandwich Protocol
IHC FF
IHC FFPE
General Western Blot Protocol
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Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.