Anti-Mouse Vγ2 TCR – DyLight® 650

Anti-Mouse Vγ2 TCR – DyLight® 650

Product No.: T594

[product_table name="All Top" skus="T594"]

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Clone
UC3-10A6
Target
Vγ 2 T-Cell Receptor
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Vγ2 T-cell receptor, T cell receptor gamma 2
Isotype
IgG
Applications
FC

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Armenian Hamster
Immunogen
G8 mouse T cells
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation
The antibody was purified by affinity chromatography and conjugated with DyLight 650 under optimal conditions.
Storage and Handling
This DyLight® 650 antibody conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Excitation Laser
Red Laser (652 nm)
Applications and Recommended Usage?
Quality Tested by Leinco
Flow Cytometry: For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. Each lot of this antibody is quality control tested.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Armenian Hamster Anti-Mouse Vγ 2 T-Cell Receptor (TCR) (Clone UC3-10A6) recognizes an epitope on Mouse TCR. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution
Vγ 2 T-Cell Receptor (TCR)-bearing T lymphocytes make up a significant proportion of γδ TCR-bearing cells in the late fetal and adult thymus and adult peripheral lymphoid tissues and lung.
Background
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a heterodimer consisting of an α and β chain in 95% of T cells, while 5% of T cells have TCRs consisting of γ and δ chains. Engagement of the TCR with antigen and MHC results in activation of its T lymphocyte through a series of biochemical events mediated by associated enzymes, co-receptors and specialized accessory molecules.

Antigen Details

Function
Might play a role in a previously unrecognized form of immunological surveillance for stress-induced self-antigens.
Research Area
Adaptive Immunity
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Immunology

References & Citations

Hedrick, S. M. et al. (1990) Nature. 343:714
Flow Cytometry
Products are for research use only. Not for use in diagnostic or therapeutic procedures.