Anti-Mouse Vγ2 TCR – DyLight^® 488

G8 mouse T cells

This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

The antibody was purified by protein a chromatography and conjugated to DyLight 488 under optimal conditions.

This DyLight^® 488 conjugate is stable when stored at 2-8°C. Do not freeze.

Next Day 2-8°C

Blue Laser (493 nm)

Armenian Hamster Anti-Mouse Vγ 2 T-Cell Receptor (Vγ 2 TCR) (Clone UC3-10A6) recognizes an epitope on Mouse Vγ 2 TCR. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody reacts with Vγ 2 T-C

Vγ 2 T-Cell Receptor (TCR)-bearing T lymphocytes make up a significant proportion of γδ TCR-bearing cells in the late fetal and adult thymus and adult peripheral lymphoid tissues and lung.

The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a heterodimer consisting of an α and β chain in 95% of T cells, while 5% of T cells have TCRs consisting of γ and δ chains. Engagement of the TCR with antigen and MHC results in activation of its T lymphocyte through a series of biochemical events mediated by associated enzymes, co-receptors and specialized accessory molecules.

Might play a role in a previously unrecognized form of immunological surveillance for stress-induced self-antigens.

Hedrick, S. M. et al. (1990) Nature. 343:714