Recombinant Human CXCL5

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Pricing & Details

Product. No.E109
Alternate Names
Chemokine (C-X-C Motif) Ligand 5, AMCF-II, Epithelial-Derived Neutrophil-Activating Peptide 78 (ENA-78), GCP-2, Scyb5, Scyb6, Lipopolysaccharide-Induced CXC Chemokine (LIX)
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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E109-25 µg
25 µg
$239.00
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Background

CXCL5 is an inflammatory chemokine that belongs to the CXC chemokine family1 that has a role in the development of cardiovascular diseases.2 CXCL5 is expressed by fibroblasts, is induced by bacterial lipopolysaccharides, and is chemotactic for neutrophils.1 It is expressed by epithelial cells within colorectal mucosa is a chemoattractant for neutrophils and has been implicated in Crohn's disease and ulcerative colitis.3 CXCL5 is important in growth and development of colorectal cancer, implicating a future role in both cancer therapy and diagnosis.4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human ENA-78, 5-78 a.a. was determined by its ability to induce myeloperoxidase release from cytochalasin B treated human neutrophils (Schröder, J. et al., 1987, J. Immunol. 139:3474) or chemotaxis of mouse BaF/3 cells transfected with human CXCR-2. The expected ED50 for these effects are typically 0.5 - 1.5 μg/ml or 0.3 - 1.5 ng/ml, respectively.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
aavlrelrcv clqttqgvhp kmisnlqvfa igpqcskvev vaslkngkei cldpeapflk kviqkildgg nken
N-terminal Sequence Analysis
Ala41
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CXCL5 is Mr 8 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Rajashekhar, G. et al. (2007) Physiol Genomics 31: 104
2. Mahsa, M. et al. (2008) Molec Diagnosis & Therapy 12: 391
3. Wågsäter, D. et al. (2007) International J Oncol. 31: 97
4. Nagelkerke, F. et al. (2008) Clinical Cancer Research 14: 2276
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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