Anti-Human CD14 – DyLight® 488

Anti-Human CD14 – DyLight® 488

Product No.: C1859

[product_table name="All Top" skus="C1859"]

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Clone
UCHM-1
Target
CD14
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
LPS Receptor
Isotype
IgG2a
Applications
FC

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Blue Laser (493 nm)
Applications and Recommended Usage?
Quality Tested by Leinco
FC The suggested concentration for this UCHM-1 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Clone UCHM-1 recognizes an epitope on human CD14.
Background
CD14 is a 53-55 kD GPI-anchored single chain glycoprotein that plays a role in the clearance of gram-negative pathogens by interacting with other proteins, including TLR-4 and MD-2, to mediate the innate immune response to bacterial lipopolysaccharide (LPS). As a high-affinity receptor for LPS, it is involved in the upregulation of adhesion molecules and cytokine expression in monocytes and neutrophils.
Antigen Distribution
CD14 is expressed on monocytes, macrophages, dendritic cells, and granulocytes.
Ligand/Receptor
LPS.
PubMed
NCBI Gene Bank ID
Research Area
Cell Biology
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Immunology
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Neuroinflammation
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Neuroscience

References & Citations

1. Ulrich Costabel et al. (1995) CHEST 108: 1614 2. Ulevitch RJ et al. (1993) Immunobiology 187: 227 3. Schumann RR et al. (1994) Medical Microbiol Immunol. 183: 279 4. Verhasselt V et al. (1997) J Immunol. 158: 2919 5. Kirkland TN et al. (2000) J Biol Chem. 275: 3144
Flow Cytometry

Certificate of Analysis

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Formats Available

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Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.