IL-21R (Extracellular Domain) Blocking Peptide

IL-21R (Extracellular Domain) Blocking Peptide

Product No.: I-355

[product_table name="All Top" skus="I-355"]

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Target
Interleukin-21 Receptor
Product Type
Blocking Peptide
Alternate Names
NILR, MGC10967

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Antibody Details

Product Details

Reactive Species
Human
Product Concentration
0.2 mg/ml
Amino Acid Location
This peptide sequence is located at amino acids 97 to 111 of Human IL-21 protein.
Formulation
This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Storage and Handling
Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Amino Acid Sequence
15 amino acids near the extracellular domain of human IL-21 Receptor.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Background
Interleukin 21 receptor (IL-21R) is a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL4RA).1 IL-21R is an important amplifier of alternative macrophage activation. Collectively, these results illustrate an essential function for the IL-21R in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases.2 IL-21/IL-21R system may represent a new target for the treatment of Adult T-cell leukaemia (ATL).3

Antigen Details

References & Citations

1. Hackstein H et al. (2003) Genes Immun. 4: 228 2. Wynn TA et al. (2006) J Clin Invest. 116: 2044 3. Uchiyama T et al. (2005) Br J Haematol. 128: 169
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.