Anti-Human CD28 – Purified in vivo PLATINUM™ Functional Grade

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Pricing & Details

Product No.C2880
Clone
CD28.2
Protein
CD28
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
MGC138290, Tp44
Isotype
Mouse
IgG1 κ
Applications
CODEX®
,
Costim
,
FC
,
IHC FF
,
IP
Prod No.
Size
Price
Avail.
Qty
Add to cart
C2880-1.0mg
1.0 mg
$198.00
In stock
Max:
Min: 1
Step: 1
C2880-5.0mg
5.0 mg
$355.00
In stock
Max:
Min: 1
Step: 1
C2880-25mg
25 mg
$995.00
In stock
Max:
Min: 1
Step: 1
C2880-50mg
50 mg
$1,500.00
In stock
Max:
Min: 1
Step: 1
C2880-100mg
100 mg
$2,220.00
In stock
Max:
Min: 1
Step: 1

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Product Concentration
≥ 2.0 mg/ml
Endotoxin Level
≤ 0.5 EU/mg as determined by the LAL method
Purity
>98% by SDS Page
Formulation
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Storage and Handling
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
FC
Other Applications Reported In Literature ?
IP
IHC FF
Costim
PhenoCycler-Fusion (CODEX)®
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone CD28.2 recognizes an epitope on human CD28.
Antigen Distribution
CD28 is expressed on thymocytes, CD4+, CD8+ peripheral T cells, NK cells.
Background
CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.

Antigen Details

Protein
Ligand/Receptor
CD80, CD86
PubMed
NCBI Gene Bank ID
Research Area
Costimulatory Molecules
.
Immunology

References & Citations

1. Stern, LJ. et al. (2005) Proc Natl Acad Sci U S A.102(10):3744-9 PubMed
Flow Cytometry
IHC
Immunoprecipitation Protocol