Anti-Mouse IFNAR-1 – Biotin

Pricing & Details

Product No.I-402
Clone
MAR1-5A3
Protein
IFNAR1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CD118, Ifar, Ifnar, Ifrc, INF-a receptor, Interferon-α/β receptor α chain precursor
Isotype
Mouse
IgG1
Applications
ELISA
,
FC
,
IP
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-402-50 µg
50 µg
$104.00
In stock
Max:
Min: 1
Step: 1
I-402-100 µg
100 µg
$187.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Mouse
Immunogen
A plasmid encoding the extracellular domain of Mouse IFNAR1
Product Concentration
0.5 mg/ml
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Applications and Recommended Usage?
Quality Tested by Leinco
FC The suggested concentration for clone MAR1-5A3 Biotin conjugated antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application.
Other Applications Reported In Literature ?
WB
IP
ELISA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone MAR1-5A3 recognizes an epitope on mouse IFNAR1.
Antigen Distribution
IFNAR1 and IFNAR2 are coexpressed on nearly all cells.
Background
IFNAR1 is a type I membrane protein, that in conjunction with IFNAR2, makes up the heterodimeric receptor that binds all type I IFNs, which includes IFN α and β. Binding and activation of the receptor stimulates Janus protein kinases, which leads to the phosphorylation of several other proteins, namely STAT1 and STAT2. IFNAR1 has also been shown to interact with PRMT1 and Tyrosine kinase 2. Type I IFNs are a family of cytokines that have been shown to promote anti-viral, anti-microbial, anti-tumor and autoimmune responses In vivo.

Antigen Details

Protein
Ligand/Receptor
IFN-α/β
PubMed
NCBI Gene Bank ID

References & Citations

1. Sheehan, K. C. F. et al. (2006) JICR 26(11):804
2. Dunn, G. P. et al. (2005) Nat. Immunol. 6(7):722
3. Fenner, J. E. et al. (2006) Nat. Immunol. 7(1):33
Elisa Sandwich Protocol
Flow Cytometry
Immunoprecipitation Protocol
General Western Blot Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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