Anti-Secretogranin II Antibody (26101)
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Antibody DetailsProduct DetailsReactive Species Squirrel Monkey ⋅ Human, Rat Host Species Rabbit Immunogen Synthetic peptide derived from the N-terminus of mature SgII protein: QRNQLLGKEPDLRLENVQK (Accession no. AAA36607). Product Concentration Lot Specific Formulation Whole antiserum State of Matter Liquid Product Preparation Whole antiserum Storage and Handling This antibody is stable for at least one (1) year at -20°C to -70°C. Avoid repeated freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use diluted 1:2,500-1:10,000. A band of ~86kDa is detected. Although the predicted mw of SgII is ~71kDa, the highly acidic nature of SgII causes it to run at a higher mw in SDS-PAGE.
Immunohistochemistry: use diluted 1:1,000. Immunoprecipitation: use diluted 1:100-1:500. Positive control: rat PC12 adrenal pheochromocytoma cells Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Polyclonal Antibody specific to Secretogranin II Background Secretogranin II (SgII), encoded by the gene SCG2, is a member of the granin family of neuroendocrine secretory proteins. The granin family also includes chromogranin A (CgA), chromogranin B (CgB), and several other secretogranin-like proteins. Studies in rodents suggest that the full-length protein, SgII, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. SgII occurs in a variety of neoplasms arising from endocrine and neuroendocrine cells and can be a useful histological tumor marker for those cells. Function Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {PubMed:19357184}. NCBI Gene Bank ID UniProt.org Research Area Hormones/Proteins References & CitationsThompson ME et al. 1992. Prolactin granulogenesis is associated with increased secretogranin expression and aggregation in the Golgi apparatus of GHvC1 cells. Endocrinology 131: 318-326. Vasauskas AA et al. 2011. Regulation and distribution of squirrel monkey chorionic gonadotropin and secretogranin II in the pituitary. General and Comparative Endocrinology 170: 509-513. Technical Protocols   Certificate of Analysis |
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