Anti-TRICK2 [Polyclonal]

Synthetic peptide corresponding to amino acids 409-427 (LGERLAKQKIEDHLLSSGK, isoform 1) of human TRICK2 precursor conjugated to KLH at the N-terminus. The same sequence is found at amino acids 380-398 in isoform 2.

PBS, pH 7.4.

Liquid

Purified by peptide immuno-affinity chromatography

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to TRICK2 (DR5,TRAIL-R2)

Apoptosis is induced by cytokines in the TNF family through their death domain containing receptors. TRICK2 (TRAIL receptor inducer of cell killing 2) is a member of the TNF receptor family and contains the conserved death domain. TRICK2 is expressed at high levels in lymphocytes and spleen cells and in many types of tumor cells. Overexpression of TRICK2 rapidly induces cell death by apoptosis. TRICK2 has been shown to function as a receptor for TRAIL and can inhibit TRAIL-induced killing of lymphocytic cells. Other names for TRICK2 include DR5, Apo2, TRAIL-R2, and KILLER.

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {PubMed:10542098, PubMed:10549288, PubMed:15322075}.