Anti-Human MIP-1α

Pricing & Details

  
Product Type
Polyclonal Antibody
Alternate Names
G0S19-1, LD78Alpha, MIP1A, SCYA3, CCL3
Applications
ELISA Indirect
,
N
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
M147-25 µg
25 µg
$175.00
In stock
M147-100 µg
100 µg
$375.00
In stock
  

Antibody Details

Reactivity Species
Human
Host Species
Goat
Immunogen
Purified Recombinant Human MIP-1α (>98%)
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Formulation
This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Storage and Handling
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Description

Specificity
Goat Anti-Human Macrophage Inflammatory Protein 1 Alpha (MIP-1α) recognizes Human MIP-1α. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
Background
Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a potent inhibitor of hemopoietic stem cell proliferation and is a member of a family of pro- inflammatory mediators, the chemokine family.1 MIP-1 alpha is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells.2 The role of MIP-1 alpha seems to be related to production of TNF-alpha, which in turn up-regulates vascular adhesion molecules required for neutrophil influx.3

Antigen Details

Protein
MIP-1 alpha
PubMed
MIP-1alpha+AND+Human
NCBI Gene Bank ID

References & Citations

1. Pragnel, IB. et al. (1994) J. Biol. Chem. 269: 4974
2. Cook, DN. et al. (1996) J. of Leukocyte Biol. 59: 61
3. Ward, PA. et al. (1995) J of Immunol. 154: 4793
Indirect Elisa Protocol
General Western Blot Protocol
  
Products are for research use only. Not for use in diagnostic or therapeutic procedures.